A peptide mimetic of human interferon (IFN)-beta.

  title={A peptide mimetic of human interferon (IFN)-beta.},
  author={Atsushi Sato and Saburo Sone},
  journal={The Biochemical journal},
  volume={371 Pt 2},
Type I interferons (IFNs) are cytokines that are used clinically as antiviral and antitumour agents. The interaction of IFNs with their heterodimeric type I IFN receptor comprised of IFNAR1 and IFNAR2 is a first step to inducing biological actions. Here, we describe the successful mimicry of IFN-beta by a peptide isolated by phage-display screening using a neutralizing anti-IFN-beta monoclonal antibody. The 15-mer peptide, designated SYR6, was shown to compete with IFN-beta for binding to type… CONTINUE READING
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