A peptide-major histocompatibility complex II chimera favors survival of pancreatic beta-islets grafted in type 1 diabetic mice.

@article{Casares2008APH,
  title={A peptide-major histocompatibility complex II chimera favors survival of pancreatic beta-islets grafted in type 1 diabetic mice.},
  author={Sofia Casares and Marvin Lin and Nan Zhang and John R. Teijaro and Cristina Stoica and Robert C. McEvoy and Donna L Farber and Constantin A. Bona and Teodor D. Brumeanu},
  journal={Transplantation},
  year={2008},
  volume={85 12},
  pages={1717-25}
}
BACKGROUND Transplantation of pancreatic islets showed a tremendous progress over the years as a promising, new therapeutic strategy in patients with type 1 diabetes. However, additional immunosuppressive drug therapy is required to prevent rejection of engrafted islets. The current immunosuppressive therapies showed limited success in maintaining long-term islet survival as required to achieve insulin independence in type 1 diabetes, and they induce severe adverse effects. Herein, we analyzed… CONTINUE READING