A peptide inhibitor of FOXP3 impairs regulatory T cell activity and improves vaccine efficacy in mice.


Immunosuppressive activity of regulatory T cells (Treg) may contribute to the progression of cancer or infectious diseases by preventing the induction of specific immune responses. Using a phage-displayed random peptide library, we identified a 15-mer synthetic peptide, P60, able to bind to forkhead/winged helix transcription factor 3 (FOXP3), a factor… (More)
DOI: 10.4049/jimmunol.1001114


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