A peptide from the GAP-binding domain of the ras-p21 protein and azatyrosine block ras-induced maturation of Xenopus oocytes.

Abstract

The ras-oncogene-encoded p21 protein causes malignant transformation of NIH 3T3 cells and maturation of Xenopus oocytes when microinjected into these cells. P21 is known to interact with GTPase activating protein (GAP) intracellularly. Residues 32-45 of p21 have been implicated in interacting with GAP. In a previous study, we demonstrated that a synthetic… (More)

Topics

Cite this paper

@article{Chung1991APF, title={A peptide from the GAP-binding domain of the ras-p21 protein and azatyrosine block ras-induced maturation of Xenopus oocytes.}, author={Denise L. Chung and Paul Wesley Brandt-Rauf and R B Murphy and S. Nishimura and Ziro Yamaizumi and I. B. Weinstein and M. R. Pincus}, journal={Anticancer research}, year={1991}, volume={11 4}, pages={1373-8} }