A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells

@article{Yamada2009APF,
  title={A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells},
  author={Tohru Yamada and R. Mehta and F. Lekmine and K. Christov and Marissa L King and D. Majumdar and A. Shilkaitis and A. Green and L. Bratescu and C. Beattie and T. D. Das Gupta},
  journal={Molecular Cancer Therapeutics},
  year={2009},
  volume={8},
  pages={2947 - 2958}
}
  • Tohru Yamada, R. Mehta, +8 authors T. D. Das Gupta
  • Published 2009
  • Medicine, Biology
  • Molecular Cancer Therapeutics
  • We report that amino acids 50 to 77 of azurin (p28) preferentially enter the human breast cancer cell lines MCF-7, ZR-75-1, and T47D through a caveolin-mediated pathway. Although p28 enters p53 wild-type MCF-7 and the isogenic p53 dominant-negative MDD2 breast cancer cell lines, p28 only induces a G2-M-phase cell cycle arrest and apoptosis in MCF-7 cells. p28 exerts its antiproliferative activity by reducing proteasomal degradation of p53 through formation of a p28:p53 complex within a… CONTINUE READING
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