A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells.

@article{Yamada2009APF,
  title={A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells.},
  author={Tohru Yamada and Rajeshwari R. Mehta and Fatima Lekmine and Konstantin T Christov and Marissa L. King and Dibyen Majumdar and Anne Shilkaitis and Albert Green and Laura Bratescu and Craig W. Beattie and Tapas K. Das Gupta},
  journal={Molecular cancer therapeutics},
  year={2009},
  volume={8 10},
  pages={2947-58}
}
We report that amino acids 50 to 77 of azurin (p28) preferentially enter the human breast cancer cell lines MCF-7, ZR-75-1, and T47D through a caveolin-mediated pathway. Although p28 enters p53 wild-type MCF-7 and the isogenic p53 dominant-negative MDD2 breast cancer cell lines, p28 only induces a G(2)-M-phase cell cycle arrest and apoptosis in MCF-7 cells. p28 exerts its antiproliferative activity by reducing proteasomal degradation of p53 through formation of a p28:p53 complex within a… CONTINUE READING

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COP1, the negative regulator Molecular Cancer Therapeutics Mol Cancer Ther 2009;8(10)

D Dornan, S Bheddah, K Newton
October 2009 2957 on June • 2009
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