A peptide derived from alpha-fetoprotein prevents the growth of estrogen-dependent human breast cancers sensitive and resistant to tamoxifen.

@article{Bennett2002APD,
  title={A peptide derived from alpha-fetoprotein prevents the growth of estrogen-dependent human breast cancers sensitive and resistant to tamoxifen.},
  author={James P. Bennett and Fassil B. Mesfin and Thomas T. Andersen and John F. Gierthy and Herbert I. Jacobson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 4},
  pages={2211-5}
}
An 8-mer peptide (EMTOVNOG) derived from alpha-fetoprotein was compared with tamoxifen for activity against growth of human breast cancer xenografts implanted in immune-deficient mice. Both peptide and tamoxifen prevented growth of estrogen-receptor-positive MCF-7 and T47D human breast cancer xenografts. A subline of MCF-7, made resistant to tamoxifen by a 6-month exposure to this drug in culture, was found to be resistant to tamoxifen in vivo. Peptide completely prevented the xenograft growth… CONTINUE READING