A peptide derived from alpha-fetoprotein inhibits the proliferation induced by estradiol in mammary tumor cells in culture.

@article{Sierralta2008APD,
  title={A peptide derived from alpha-fetoprotein inhibits the proliferation induced by estradiol in mammary tumor cells in culture.},
  author={Walter Daniel Sierralta and Mar{\'i}a Jos{\'e} Epu{\~n}{\'a}n and Jos{\'e} Mart{\'i}nez Reyes and Luis Emilio Valladares and Thomas T. Andersen and James A. Bennett and Herbert I. Jacobson and Ana Mar{\'i}a Moure Pino},
  journal={Oncology reports},
  year={2008},
  volume={19 1},
  pages={
          229-35
        }
}
This study was aimed to obtain additional information on the activity of a cyclized 9-amino acid peptide (cP) containing the active site of alpha fetoprotein, which inhibits the estrogen-stimulated proliferation of tumor cells in culture and of xenografts in immunodeficient mice. Breast cancer cells cultured in the presence of 2 nM estradiol were exposed to cP for different periods and their proliferation, estradiol binding parameters, clustering tendency and expression of E-cadherin and… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES