A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator.

@article{Atlante2008APC,
  title={A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator.},
  author={Anna Atlante and G Amadoro and Antonella Bobba and Lidia de Bari and Veronica Corsetti and Giuseppe Pappalardo and Ersilia Marra and Pietro Calissano and Salvatore Passarella},
  journal={Biochimica et biophysica acta},
  year={2008},
  volume={1777 10},
  pages={1289-300}
}
Having confirmed that adenovirus-mediated overexpression of NH(2)-tau fragment lacking the first 25 aminoacids evokes a potent neurotoxic effect, sustained by protracted stimulation of NMDA receptors, in primary neuronal cultures we investigated whether and how chemically synthesized NH(2)-derived tau peptides, i.e. NH(2)-26-44 and NH(2)-1-25 fragments, affect mitochondrial function. We tested both fragments on each step of the processes leading to ATP synthesis via oxidative phosphorylation: i… CONTINUE READING

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