A pentose bisphosphate pathway for nucleoside degradation in Archaea.

Abstract

Owing to the absence of the pentose phosphate pathway, the degradation pathway for the ribose moieties of nucleosides is unknown in Archaea. Here, in the archaeon Thermococcus kodakarensis, we identified a metabolic network that links the pentose moieties of nucleosides or nucleotides to central carbon metabolism. The network consists of three nucleoside… (More)
DOI: 10.1038/nchembio.1786

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