A penalized robust semiparametric approach for gene-environment interactions.

@article{Wu2015APR,
  title={A penalized robust semiparametric approach for gene-environment interactions.},
  author={Cen Wu and Xingjie Shi and Yuehua Cui and Shuangge Ma},
  journal={Statistics in medicine},
  year={2015},
  volume={34 30},
  pages={4016-30}
}
In genetic and genomic studies, gene-environment (G×E) interactions have important implications. Some of the existing G×E interaction methods are limited by analyzing a small number of G factors at a time, by assuming linear effects of E factors, by assuming no data contamination, and by adopting ineffective selection techniques. In this study, we propose a new approach for identifying important G×E interactions. It jointly models the effects of all E and G factors and their interactions. A… CONTINUE READING
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