A pen-and-paper human analogue of a monkey prefrontal cortex activation task: spatial working memory in patients with schizophrenia

@article{Keefe1995APH,
  title={A pen-and-paper human analogue of a monkey prefrontal cortex activation task: spatial working memory in patients with schizophrenia},
  author={Richard S. E. Keefe and Sonia E. Lees Roitman and Philip D. Harvey and Cynthia S. Blum and Kenneth L. Davis},
  journal={Schizophrenia Research},
  year={1995},
  volume={17},
  pages={25-33}
}
In order to pursue the hypothesis that the dorsolateral prefrontal cortex is a source of cognitive deficit in schizophrenia, we developed an easily administered pen-and-paper human analogue of a visuospatial working memory task that in non-human primates activates the neurons of Walker area 46 (Goldman-Rakic, 1987). Compared to normal controls, schizophrenic patients made significantly greater errors in identifying where a visuospatial stimulus had been presented to them 30 and 60 seconds… CONTINUE READING
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