A peek at ice binding by antifreeze proteins.

  • Kim A. Sharp
  • Published 2011 in
    Proceedings of the National Academy of Sciences…


W hat is the toughest recognition problem in biology? Arguably, it is that faced by antifreeze or thermal hysteresis proteins. These proteins provide a broad range of organisms with protection against freezing damage by depressing, in a noncolligative manner, the freezing point of water. They do this by binding to nascent ice nuclei and inhibiting their… (More)
DOI: 10.1073/pnas.1104618108


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