A peek at ice binding by antifreeze proteins.

@article{Sharp2011APA,
  title={A peek at ice binding by antifreeze proteins.},
  author={Kim A. Sharp},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 18},
  pages={
          7281-2
        }
}
What is the toughest recognition problem in biology? Arguably, it is that faced by antifreeze or thermal hysteresis proteins. These proteins provide a broad range of organisms with protection against freezing damage by depressing, in a noncolligative manner, the freezing point of water. They do this by binding to nascent ice nuclei and inhibiting their growth (1). In other words, antifreeze proteins (AFPs) must distinguish one phase of water, ice, from another phase, liquid. Moreover, the… CONTINUE READING

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