A pathway that links reproductive status to lifespan in Caenorhabditis elegans.

@article{Kenyon2010APT,
  title={A pathway that links reproductive status to lifespan in Caenorhabditis elegans.},
  author={Cynthia J. Kenyon},
  journal={Annals of the New York Academy of Sciences},
  year={2010},
  volume={1204},
  pages={
          156-62
        }
}
In the nematode Caenorhabditis elegans and the fruit fly Drosophila, loss of the germline stem cells activates lifespan-extending FOXO-family transcription factors in somatic tissues and extends lifespan, suggesting the existence of an evolutionarily conserved pathway that links reproductive state and aging. Consistent with this idea, reproductive tissues have been shown to influence the lifespans of mice and humans as well. In C. elegans, loss of the germ cells activates a pathway that… CONTINUE READING
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