A pathway for conformational diversity in proteins mediated by intramolecular chaperones.

@article{Shinde1999APF,
  title={A pathway for conformational diversity in proteins mediated by intramolecular chaperones.},
  author={Ujwal Shinde and Xiaolin Fu and M. Inouye},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 22},
  pages={15615-21}
}
Conformational diversity within unique amino acid sequences is observed in diseases like scrapie and Alzheimer's disease. The molecular basis of such diversity is unknown. Similar phenomena occur in subtilisin, a serine protease homologous with eukaryotic pro-hormone convertases. The subtilisin propeptide functions as an intramolecular chaperone (IMC) that… CONTINUE READING