A pathway branching in transcription initiation in Escherichia coli

@article{Susa2006APB,
  title={A pathway branching in transcription initiation in Escherichia coli},
  author={Motoki Susa and Tomoko Kubori and Nobuo Shimamoto},
  journal={Molecular Microbiology},
  year={2006},
  volume={59},
  pages={1807 - 1817}
}
In transcription initiation, all RNA polymerase molecules bound to a promoter have been conventionally supposed to proceed into elongation of transcript. However, for Escherichia coli RNA polymerase, evidence has been accumulated for a view that only its fraction can proceed into elongation and the rest is retained at a promoter in non-productive form: a pathway branching in transcription initiation. Proteins such as GreA and GreB affect these fractions at several promoters in vitro. To reveal… CONTINUE READING