A pathway-based classification of human breast cancer.

@article{Gatza2010APC,
  title={A pathway-based classification of human breast cancer.},
  author={Michael L. Gatza and Joseph E. Lucas and William T. Barry and Jong Wook Kim and Quanli Wang and Matthew D. Crawford and Michael B. Datto and Michael Kelley and Bernard Mathey-Prevot and A. De Potti and J. R. Nevins},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 15},
  pages={
          6994-9
        }
}
The hallmark of human cancer is heterogeneity, reflecting the complexity and variability of the vast array of somatic mutations acquired during oncogenesis. An ability to dissect this heterogeneity, to identify subgroups that represent common mechanisms of disease, will be critical to understanding the complexities of genetic alterations and to provide a framework to develop rational therapeutic strategies. Here, we describe a classification scheme for human breast cancer making use of patterns… CONTINUE READING

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