A pathophysiological role of TRPV1 in ischemic injury after transient focal cerebral ischemia in mice.

@article{Miyanohara2015APR,
  title={A pathophysiological role of TRPV1 in ischemic injury after transient focal cerebral ischemia in mice.},
  author={Jun Miyanohara and Hisashi Shirakawa and Kazuaki Sanpei and Takayuki Nakagawa and Shuji Kaneko},
  journal={Biochemical and biophysical research communications},
  year={2015},
  volume={467 3},
  pages={478-83}
}
Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel with high Ca(2+) permeability, which functions as a polymodal nociceptor activated by heat, protons and several vanilloids, including capsaicin and anandamide. Although TRPV1 channels are widely distributed in the mammalian brain, their pathophysiological roles in the brain remain to be elucidated. In this study, we investigated whether TRPV1 is involved in cerebral ischemic injury using a middle cerebral artery… CONTINUE READING

Similar Papers

Loading similar papers…