A pathophysiologic role for T lymphocytes in murine acute cisplatin nephrotoxicity.

@article{Liu2006APR,
  title={A pathophysiologic role for T lymphocytes in murine acute cisplatin nephrotoxicity.},
  author={Manchang Liu and Chu-Chun Chien and Melissa J. Burne-Taney and Roshni R Molls and Lorraine C. Racusen and Robert B. Colvin and Hamid Rabb},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2006},
  volume={17 3},
  pages={765-74}
}
Recent evidence supports a role for an inflammatory pathogenesis of cisplatin nephrotoxicity, but immune cell-mediated mechanisms in this disease are still largely unknown. The role for T lymphocytes on cisplatin-induced acute kidney injury was examined with C57BL/6 T cell-deficient (nu/nu) mice and CD4- or CD8-deficient mice and their wild-type (WT) littermates. All mice received a single dose of cisplatin at 40 mg/kg (intraperitoneally) and were followed up for 72 h. At 72 h after cisplatin… CONTINUE READING