A pathogenic role for IgE in autoimmunity: bullous pemphigoid IgE reproduces the early phase of lesion development in human skin grafted to nu/nu mice.

@article{Fairley2007APR,
  title={A pathogenic role for IgE in autoimmunity: bullous pemphigoid IgE reproduces the early phase of lesion development in human skin grafted to nu/nu mice.},
  author={Janet A. Fairley and Christopher T. Burnett and Chang-Ling Fu and David L. Larson and Matthew G. Fleming and George J. Giudice},
  journal={The Journal of investigative dermatology},
  year={2007},
  volume={127 11},
  pages={
          2605-11
        }
}
Bullous pemphigoid (BP) is an autoimmune disease characterized by subepidermal blistering. Based on previous work, IgG autoantibodies directed against BP180 are thought to be the primary pathogenic agent in BP. In addition to these IgG autoantibodies, however, most BP patients produce IgE class autoantibodies that also react with BP180, and total IgE levels are often elevated in this disease. To directly test whether BP IgE is pathogenic, 6 ng of total IgE isolated from two BP and two normal… CONTINUE READING

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