A passion for P450s (rememberances of the early history of research on cytochrome P450).

@article{Estabrook2003APF,
  title={A passion for P450s (rememberances of the early history of research on cytochrome P450).},
  author={Ronald W. Estabrook},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2003},
  volume={31 12},
  pages={
          1461-73
        }
}
  • R. Estabrook
  • Published 1 December 2003
  • Biology
  • Drug metabolism and disposition: the biological fate of chemicals
Many members of the superfamily of hemeproteins, known as cytochrome P450 (P450 or CYP), are currently described in the literature (over 2000 at the date of this writing) [see Nelson, 2003 (http://drnelson.utmem.edu/CytochromeP450.html)]. In mammalian tissues, the P450s play central roles in drug and xenobiotic metabolism as well as steroid hormone synthesis, fat-soluble vitamin metabolism, and the conversion of polyunsaturated fatty acids to biologically active molecules. P450s also play a… 

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