A parkinsonian syndrome induced in the goldfish by the neurotoxin MPTP.

@article{Pollard1992APS,
  title={A parkinsonian syndrome induced in the goldfish by the neurotoxin MPTP.},
  author={Harvey B Pollard and K Dhariwal and Oluwadare M. Adeyemo and Carol Markey and Hung Caohuy and Maurice Levine and Sanford P. Markey and Moussa B. H. Youdim},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1992},
  volume={6 12},
  pages={
          3108-16
        }
}
Parkinson's disease has been modeled in humans, lower primates, and to a lesser extent in some other vertebrates by administration of the potent neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine). The MPTP model has thus drawn considerable attention as a system to search for anti-Parkinson's disease drugs, although the cost and scarcity of primates has limited extensive applications. We now report that a parkinsonian syndrome can be elicited in the common goldfish (Carassius auratus… CONTINUE READING

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