A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

@article{Iliff2012APP,
  title={A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.},
  author={Jeffrey J Iliff and Minghuan Wang and Yonghong Liao and Benjamin A. Plogg and Weiguo Peng and Georg Andreas Gundersen and Helene Benveniste and George Edward Vates and Rashid Deane and Steven A Goldman and Erlend A. Nagelhus and Maiken Nedergaard},
  journal={Science translational medicine},
  year={2012},
  volume={4 147},
  pages={147ra111}
}
Because it lacks a lymphatic circulation, the brain must clear extracellular proteins by an alternative mechanism. The cerebrospinal fluid (CSF) functions as a sink for brain extracellular solutes, but it is not clear how solutes from the brain interstitium move from the parenchyma to the CSF. We demonstrate that a substantial portion of subarachnoid CSF cycles through the brain interstitial space. On the basis of in vivo two-photon imaging of small fluorescent tracers, we showed that CSF… CONTINUE READING
Highly Influential
This paper has highly influenced 79 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
582 Citations
55 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 582 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Similar Papers

Loading similar papers…