A parametric analysis of punishment frequency as a determinant of the response to chlordiazepoxide in the Vogel conflict test in rats.

Abstract

The Vogel conflict test has been widely used as a methodology for detecting anxiolytic-like effects of drugs with a broad spectrum of pharmacological activities. Despite widespread acceptance of the Vogel assay as a preclinical predictor of efficacy for anxiolytic-like compounds, detailed parametrics have not been reported on the optimization of this assay… (More)

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