A paradigm shift: vaccine-induced antibodies as an immune correlate of protection against herpes simplex virus type 1 genital herpes.

More than a half-billion people worldwide are infected with genital herpes [1]. During primary infection, herpes simplex virus (HSV) establishes latency in lumbosacral dorsal root ganglia. The natural history of genital herpes is characterized by frequent episodes of recurrences that may be symptomatic or asymptomatic and that transmit virus to sexual… CONTINUE READING