A paper which changed clinical practice (slowly). Jacob Holler on potassium deficiency in diabetic acidosis (1946).

@article{Tattersall1999APW,
  title={A paper which changed clinical practice (slowly). Jacob Holler on potassium deficiency in diabetic acidosis (1946).},
  author={R. B. Tattersall},
  journal={Diabetic medicine : a journal of the British Diabetic Association},
  year={1999},
  volume={16 12},
  pages={978-84}
}
  • R. B. Tattersall
  • Published 1999 in
    Diabetic medicine : a journal of the British…
It is often said that the introduction of insulin into clinical medicine made a 'dramatic' difference to the mortality resulting from diabetic coma. This is true in the sense that before 1922 it was almost uniformly fatal, but until the 1950s the mortality in many large hospitals was as high as 30-50%. Often autopsy did not establish a cause of death. Many may have been a result of hypokalaemia, a complication which was not recognized until 1946; in that year in the Journal of the American… CONTINUE READING