A pantothenate kinase from Staphylococcus aureus refractory to feedback regulation by coenzyme A.

@article{Leonardi2005APK,
  title={A pantothenate kinase from Staphylococcus aureus refractory to feedback regulation by coenzyme A.},
  author={Roberta Leonardi and Shigeru Chohnan and Yong-mei Zhang and Kristopher G. Virga and Richard E. Lee and Charles O Rock and Suzanne Jackowski},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 5},
  pages={3314-22}
}
The key regulatory step in CoA biosynthesis in bacteria and mammals is pantothenate kinase (CoaA), which governs the intracellular concentration of CoA through feedback regulation by CoA and its thioesters. CoaA from Staphylococcus aureus (SaCoaA) has a distinct primary sequence that is more similar to the mammalian pantothenate kinases than the prototypical bacterial CoaA of Escherichia coli. In contrast to all known pantothenate kinases, SaCoaA activity is not feedback-regulated by CoA or CoA… CONTINUE READING
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