A panel of genes methylated with high frequency in colorectal cancer

  title={A panel of genes methylated with high frequency in colorectal cancer},
  author={Susan M. Mitchell and Jason P. Ross and Horace R. Drew and Thu Ho and Glenn S. Brown and Neil F. W. Saunders and Konsta R Duesing and Michael J. Buckley and Rob Dunne and Iain Beetson and Keith N. Rand and Aidan McEvoy and Melissa L. Thomas and Rohan T. Baker and David A. Wattchow and Graeme P. Young and Trevor J. Lockett and Susanne K. Pedersen and Lawrence C Lapointe and P. L. Molloy},
  booktitle={BMC Cancer},
The development of colorectal cancer (CRC) is accompanied by extensive epigenetic changes, including frequent regional hypermethylation particularly of gene promoter regions. Specific genes, including SEPT9, VIM1 and TMEFF2 become methylated in a high fraction of cancers and diagnostic assays for detection of cancer-derived methylated DNA sequences in blood and/or fecal samples are being developed. There is considerable potential for the development of new DNA methylation biomarkers or panels… CONTINUE READING
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