A panel of ancestry informative markers for estimating individual biogeographical ancestry and admixture from four continents: utility and applications

@article{Halder2008APO,
  title={A panel of ancestry informative markers for estimating individual biogeographical ancestry and admixture from four continents: utility and applications},
  author={Indrani Halder and Mark David Shriver and Mattern Thomas and Jos{\'e} R. Fern{\'a}ndez and Tony N. Frudakis},
  journal={Human Mutation},
  year={2008},
  volume={29}
}
Autosomal ancestry informative markers (AIMs) are useful for inferring individual biogeographical ancestry (I‐BGA) and admixture. Ancestry estimates obtained from Y and mtDNA are useful for reconstructing population expansions and migrations in our recent past but individual genomic admixture estimates are useful to test for association of admixture with phenotypes, as covariate in association studies to control for stratification and, in forensics, to estimate certain overt phenotypes from… Expand
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258 Citations

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Straightforward Inference of Ancestry and Admixture Proportions through Ancestry-Informative Insertion Deletion Multiplexing
TLDR
A set of 46 ancestry-informative insertion deletion polymorphisms selected to efficiently measure population admixture proportions of four different origins are presented, enabling a more straightforward alternative to the commonly available AIM-SNP typing methods dependent on complex, multi-step protocols or implementation of large-scale genotyping technologies. Expand
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The ability to detect biogeographical ancestry in 85 individuals from self-declared Asian and European admixed families is assessed using a set of uniparental (Y and mitochondrial DNA) and autosomal single nucleotide polymorphisms, specifically selected to distinguish between these twoBiogeographical ancestries. Expand
Assessing individual interethnic admixture and population substructure using a 48–insertion‐deletion (INSEL) ancestry‐informative marker (AIM) panel
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The ability to accurately infer interethnic admixtures highlights the usefulness of this marker set for assessing population substructure in association studies, particularly those conducted in Brazilian and other Latin American populations sharing trihybrid ancestry patterns. Expand
Analysis of genetic ancestry in the admixed Brazilian population from Rio de Janeiro using 46 autosomal ancestry-informative indel markers
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The inter-ethnic admixture landscape of Rio de Janeiro captured by autosomal AIM-Indels is in agreement with historical records and similar to that expected from uniparental mtDNA and Y-chromosome information. Expand
Analyses of a set of 128 ancestry informative single-nucleotide polymorphisms in a global set of 119 population samples
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The simultaneous importance of the specific set of population samples and their relative sample sizes in the use of the structure program to determine which groups cluster together and consequently influence the ability of a marker panel to infer ancestry is demonstrated. Expand
A Panel of Ancestry Informative Markers for the Complex Five-Way Admixed South African Coloured Population
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It is shown that a panel of 96 AIMs can be used to assess ancestry proportions and to adjust for the confounding effect of the complex five-way admixture that occurred in the South African Coloured population. Expand
Developing a novel panel of genome-wide ancestry informative markers for bio-geographical ancestry estimates.
TLDR
A genome-wide scan for SNPs within genes that are related to physical and biological traits was performed and a panel of ancestry-informative markers provided accurate estimates of individual ancestry proportions with balanced discriminatory power among the three continental ancestries: Africans, Europeans, and East Asians. Expand
An Ancestry Informative Marker Set Which Recapitulates the Known Fine Structure of Populations in South Asia
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Ancestry composition and multiple phylogenetic analysis demonstrated that the geographically isolated Qiongzhong Hlai harbored a close phylogenetic relationship with Austronesian speakers and possessed a homogenous Tai-Kadai-dominant ancestry, which could be used as the ancestral source proxy in population history reconstruction ofTai-KADai-speaking populations and as one of the representatives for forensic database establishment. Expand
Massively parallel sequencing of 165 ancestry-informative SNPs and forensic biogeographical ancestry inference in three southern Chinese Sinitic/Tai-Kadai populations.
TLDR
Ancestry composition and multiple phylogenetic analysis demonstrated that the geographically isolated Qiongzhong Hlai harbored a close phylogenetic relationship with Austronesian speakers and possessed a homogenous Tai-Kadai-dominant ancestry, which could be used as the ancestral source proxy in population history reconstruction ofTai-KADai-speaking populations and as one of the representatives for forensic database establishment. Expand
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