A pancreatic islet-specific microRNA regulates insulin secretion

  title={A pancreatic islet-specific microRNA regulates insulin secretion},
  author={M. Poy and L. Eliasson and Jan Krutzfeldt and S. Kuwajima and Xiaosong Ma and Patrick E. MacDonald and S. Pfeffer and T. Tuschl and N. Rajewsky and P. Rorsman and M. Stoffel},
  • M. Poy, L. Eliasson, +8 authors M. Stoffel
  • Published 2004
  • Medicine, Biology
  • Nature
  • MicroRNAs (miRNAs) constitute a growing class of non-coding RNAs that are thought to regulate gene expression by translational repression. Several miRNAs in animals exhibit tissue-specific or developmental-stage-specific expression, indicating that they could play important roles in many biological processes. To study the role of miRNAs in pancreatic endocrine cells we cloned and identified a novel, evolutionarily conserved and islet-specific miRNA (miR-375). Here we show that overexpression of… CONTINUE READING
    MicroRNAs Regulate the Wnt/Ca2+ Signaling Pathway to Promote the Secretion of Insulin in Pancreatic Nestin-Positive Progenitor Cells
    • 1
    • Highly Influenced
    • PDF
    MiR-30 family and EMT in human fetal pancreatic islets.
    • 26
    The small RNA miR-375 – a pancreatic islet abundant miRNA with multiple roles in endocrine beta cell function
    • 39
    MiR-375, a microRNA related to diabetes.
    • X. Li
    • Biology, Medicine
    • 2014
    • 65
    Expression of islet-specific microRNAs during human pancreatic development.
    • 210
    • Highly Influenced
    Transcriptional Mechanisms Controlling miR-375 Gene Expression in the Pancreas
    • 13
    • PDF


    Publications referenced by this paper.
    Role of MicroRNAs in Plant and Animal Development
    • 1,601
    • PDF
    Computational identification of microRNA targets
    • 227
    • PDF