A pancreatic islet-specific microRNA regulates insulin secretion

@article{Poy2004API,
  title={A pancreatic islet-specific microRNA regulates insulin secretion},
  author={M. Poy and L. Eliasson and Jan Krutzfeldt and S. Kuwajima and Xiaosong Ma and Patrick E. MacDonald and S. Pfeffer and T. Tuschl and N. Rajewsky and P. Rorsman and M. Stoffel},
  journal={Nature},
  year={2004},
  volume={432},
  pages={226-230}
}
  • M. Poy, L. Eliasson, +8 authors M. Stoffel
  • Published 2004
  • Medicine, Biology
  • Nature
  • MicroRNAs (miRNAs) constitute a growing class of non-coding RNAs that are thought to regulate gene expression by translational repression. Several miRNAs in animals exhibit tissue-specific or developmental-stage-specific expression, indicating that they could play important roles in many biological processes. To study the role of miRNAs in pancreatic endocrine cells we cloned and identified a novel, evolutionarily conserved and islet-specific miRNA (miR-375). Here we show that overexpression of… CONTINUE READING
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