A palmitoylation cycle dynamically regulates partitioning of the GABA-synthesizing enzyme GAD65 between ER-Golgi and post-Golgi membranes.

@article{Kanaani2008APC,
  title={A palmitoylation cycle dynamically regulates partitioning of the GABA-synthesizing enzyme GAD65 between ER-Golgi and post-Golgi membranes.},
  author={Jamil Kanaani and George Patterson and Fred J. Schaufele and Jennifer Lippincott-Schwartz and Steinunn Baekkeskov},
  journal={Journal of cell science},
  year={2008},
  volume={121 Pt 4},
  pages={
          437-49
        }
}
GAD65, the smaller isoform of the enzyme glutamic acid decarboxylase, synthesizes GABA for fine-tuning of inhibitory neurotransmission. GAD65 is synthesized as a soluble hydrophilic protein but undergoes a hydrophobic post-translational modification and becomes anchored to the cytosolic face of Golgi membranes. A second hydrophobic modification, palmitoylation of Cys30 and Cys45 in GAD65, is not required for the initial membrane anchoring but is crucial for post-Golgi trafficking of the protein… CONTINUE READING

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