A pair of highly conserved two-component systems participates in the regulation of the hypervariable FIR proteins in different Legionella species.

@article{Feldman2007APO,
  title={A pair of highly conserved two-component systems participates in the regulation of the hypervariable FIR proteins in different Legionella species.},
  author={Michal Feldman and Gil Segal},
  journal={Journal of bacteriology},
  year={2007},
  volume={189 9},
  pages={
          3382-91
        }
}
Legionella pneumophila and other pathogenic Legionella species multiply inside protozoa and human macrophages by using the Icm/Dot type IV secretion system. The IcmQ protein, which possesses pore-forming activity, and IcmR, which functions as its chaperone, are two essential components of this system. It was previously shown that in 29 Legionella species, a large hypervariable-gene family (fir genes) is located upstream from a conserved icmQ gene, but although nonhomologous, the FIR proteins… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 59 REFERENCES

The pleiotropic two-component regulatory system PhoP-PhoQ.

  • Journal of bacteriology
  • 2001
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Identification of the core transmembrane complex of the Legionella Dot / Icm type IV secretion system

H. L. Andrews, S. K. Wong
  • Mol . Microbiol .
  • 2006