A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast.

@article{Dupressor2011APO,
  title={A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast.},
  author={Anne Dupresso{\'i}r and C{\'e}cile Vernochet and Francis Harper and Justine Gu{\'e}gan and Philippe Dessen and G{\'e}rard Pierron and T. Heidmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 46},
  pages={E1164-73}
}
In most mammalian species, a critical step of placenta development is the fusion of trophoblast cells into a multinucleated syncytiotrophoblast layer fulfilling essential fetomaternal exchange functions. Key insights into this process came from the discovery of envelope genes of retroviral origin, the syncytins, independently acquired by the human (syncytin-1 and -2), mouse (syncytin-A and -B), and rabbit (syncytin-Ory1) genomes, with fusogenic properties and placenta-specific expression. We… CONTINUE READING