A pair of circularly permutated PDZ domains control RseP, the S2P family intramembrane protease of Escherichia coli.


The sigma(E) pathway of extracytoplasmic stress responses in Escherichia coli is activated through sequential cleavages of the anti-sigma(E) protein, RseA, by membrane proteases DegS and RseP. Without the first cleavage by DegS, RseP is unable to cleave full-length RseA. We previously showed that a PDZ-like domain in the RseP periplasmic region is essential… (More)
DOI: 10.1074/jbc.M806603200


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