A packing mechanism for nucleosome organization reconstituted across a eukaryotic genome.

@article{Zhang2011APM,
  title={A packing mechanism for nucleosome organization reconstituted across a eukaryotic genome.},
  author={Zhenhai Zhang and Christian J Wippo and Megha Wal and Elissa Ward and Philipp Korber and B. Franklin Pugh},
  journal={Science},
  year={2011},
  volume={332 6032},
  pages={977-80}
}
Near the 5' end of most eukaryotic genes, nucleosomes form highly regular arrays that begin at canonical distances from the transcriptional start site. Determinants of this and other aspects of genomic nucleosome organization have been ascribed to statistical positioning, intrinsically DNA-encoded positioning, or some aspect of transcription initiation. Here, we provide evidence for a different explanation. Biochemical reconstitution of proper nucleosome positioning, spacing, and occupancy… CONTINUE READING
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