A pH-dependent phospholipase A2 contributes to loss of plasma membrane integrity during chemical hypoxia in rat hepatocytes.

Abstract

Previous studies have suggested that alterations in phospholipid composition of plasma membranes may underlie lethal cell injury due to hypoxic and ischemic injury. The present study was designed to determine if such alterations are due to the activation of a pH-dependent phospholipase A2. Loss of cell viability and phospholipase A2 activity measured by… (More)

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@article{Harrison1991APP, title={A pH-dependent phospholipase A2 contributes to loss of plasma membrane integrity during chemical hypoxia in rat hepatocytes.}, author={D. C. Harrison and John J. Lemasters and B. Herman}, journal={Biochemical and biophysical research communications}, year={1991}, volume={174 2}, pages={654-9} }