A p75NTR and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein

@article{Wong2002APA,
  title={A p75NTR and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein},
  author={Scott T. Wong and John R. Henley and Kevin C. Kanning and Kuo-hua Huang and Mark A Bothwell and Mu-Ming Poo},
  journal={Nature Neuroscience},
  year={2002},
  volume={5},
  pages={1302-1308}
}
Myelin-associated glycoprotein (MAG), an inhibitor of axon regeneration, binds with high affinity to the Nogo-66 receptor (NgR). Here we report that the p75 neurotrophin receptor (p75NTR) is a co-receptor of NgR for MAG signaling. In cultured human embryonic kidney (HEK) cells expressing NgR, p75NTR was required for MAG-induced intracellular Ca2+ elevation. Co-immunoprecipitation showed an association of NgR with p75NTR that can be disrupted by an antibody against p75NTR (NGFR5), and extensive… CONTINUE READING
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