A p53-type response element in the GDF15 promoter confers high specificity for p53 activation.

@article{Osada2007APR,
  title={A p53-type response element in the GDF15 promoter confers high specificity for p53 activation.},
  author={Motonobu Osada and Hannah Lui Park and Min Joo Park and Jun-wei Liu and Guojun Wu and Barry Trink and David Sidransky},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={354 4},
  pages={913-8}
}
GDF15 is a transcriptional target gene for p53 and its family members, p63 and p73. Its promoter region contains two p53-type response elements, RE1 and RE2, and RE2 confers p53-specific transactivation. RE2 contains several mismatches from the canonical p53 response element (RRRCWWGYYY). Two mismatches in the RRR span and T base of the RE2 core sequence in the most 3' quarter-site are critical for inhibiting the binding affinity to p63 and p73 and corresponding promoter activity. Our results… CONTINUE READING

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