A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

@article{Marin2009APD,
  title={A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity},
  author={Rosa Mar{\'i}a Mari{\'o}n and Katerina Strati and Han Li and Matilde Murga and Raquel Blanco and S. Ortega and Oscar Fern{\'a}ndez-Capetillo and Manuel Serrano and Maria A Blasco},
  journal={Nature},
  year={2009},
  volume={460},
  pages={1149-1153}
}
The reprogramming of differentiated cells to pluripotent cells (induced pluripotent stem (iPS) cells) is known to be an inefficient process. We recently reported that cells with short telomeres cannot be reprogrammed to iPS cells despite their normal proliferation rates, probably reflecting the existence of ‘reprogramming barriers’ that abort the reprogramming of cells with uncapped telomeres. Here we show that p53 (also known as Trp53 in mice and TP53 in humans) is critically involved in… CONTINUE READING
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