A p53-dependent mouse spindle checkpoint.

  title={A p53-dependent mouse spindle checkpoint.},
  author={St. Cross and Carissa A. Sanchez and Cecilia Morgan and M K Schimke and Stig Ramel and Rejean L. Idzerda and Wendy H Raskind and Brian J. Reid},
  volume={267 5202},
Cell cycle checkpoints enhance genetic fidelity by causing arrest at specific stages of the cell cycle when previous events have not been completed. The tumor suppressor p53 has been implicated in a G1 checkpoint. To investigate whether p53 also participates in a mitotic checkpoint, cultured fibroblasts from p53-deficient mouse embryos were exposed to spindle inhibitors. The fibroblasts underwent multiple rounds of DNA synthesis without completing chromosome segregation, thus forming tetraploid… CONTINUE READING
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