A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q− syndrome

@inproceedings{Barlow2010APM,
  title={A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q− syndrome},
  author={Jillian L Barlow and Lesley F. Drynan and Duncan R Hewett and Luke R. Holmes and Silvia Lorenzo-Abalde and Alison L. Lane and Helen E. Jolin and Richard Pannell and Angela J. Middleton and See Heng Wong and Alan J Warren and J Stephen Wainscoat and Jacqueline Boultwood and Andrew N. J. McKenzie},
  booktitle={Nature Medicine},
  year={2010}
}
The identification of the genes associated with chromosomal translocation breakpoints has fundamentally changed understanding of the molecular basis of hematological malignancies. By contrast, the study of chromosomal deletions has been hampered by the large number of genes deleted and the complexity of their analysis. We report the generation of a mouse model for human 5q– syndrome using large-scale chromosomal engineering. Haploinsufficiency of the Cd74–Nid67 interval (containing Rps14… CONTINUE READING
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Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function

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