A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides.

@article{Agarwal1998APS,
  title={A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides.},
  author={M. L. Agarwal and Anju Agarwal and William R Taylor and Olga B. Chernova and Yogendra Sharma and George R Stark},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 25},
  pages={14775-80}
}
Normal mammalian cells arrest primarily in G1 in response to N-(phosphonacetyl)-L-aspartate (PALA), which starves them for pyrimidine nucleotides, and do not generate or tolerate amplification of the CAD gene, which confers resistance to PALA. Loss of p53, accompanied by loss of G1 arrest, permits CAD gene amplification and the consequent formation of PALA-resistant colonies. We have found rat and human cell lines that retain wild-type p53 but have lost the ability to arrest in G1 in response… CONTINUE READING
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