A p53 codon 72 polymorphism associated with prostate cancer development and progression in Japanese.

@article{Suzuki2003APC,
  title={A p53 codon 72 polymorphism associated with prostate cancer development and progression in Japanese.},
  author={Kazuhiro Suzuki and Hiroshi Matsui and Nobuaki Ohtake and Seiji Nakata and Tomoyuki Takei and Haruki Nakazato and Hironobu Okugi and Hidekazu Koike and Yoshihiro Ono and Kazuto Ito and Kohei Kurokawa and Hidetoshi Yamanaka},
  journal={Journal of biomedical science},
  year={2003},
  volume={10 4},
  pages={430-5}
}
An association between the Pro/Pro genotype of p53 codon 72 and a lower risk of prostate cancer in Caucasians was recently reported. However, the association of this polymorphism with prostate cancer risk in a Japanese population has not been clarified. We performed a case-control study consisting of 114 prostate cancer patients and 105 noncancer controls. Sixty-nine percent (79 of 114) of the patients had a positive family history. The genotypic frequencies in the controls were 39.0% for Arg… CONTINUE READING