A p53 Drug Response Signature Identifies Prognostic Genes in High-Risk Neuroblastoma

@inproceedings{Barbieri2013APD,
  title={A p53 Drug Response Signature Identifies Prognostic Genes in High-Risk Neuroblastoma},
  author={Eveline Barbieri and Katleen de Preter and Mario Capasso and Peter Johansson and Tsz-Kwong Man and Zaowen Chen and Paris N. Stowers and Gian Paolo Tonini and Frank Speleman and Jason Matthew Shohet},
  booktitle={PloS one},
  year={2013}
}
Chemotherapy induces apoptosis and tumor regression primarily through activation of p53-mediated transcription. Neuroblastoma is a p53 wild type malignancy at diagnosis and repression of p53 signaling plays an important role in its pathogenesis. Recently developed small molecule inhibitors of the MDM2-p53 interaction are able to overcome this repression and potently activate p53 dependent apoptosis in malignancies with intact p53 downstream signaling. We used the small molecule MDM2 inhibitor… CONTINUE READING