A p38 inhibitor allows to dissociate differentiation and apoptotic processes triggered upon LIF withdrawal in mouse embryonic stem cells

@article{Duval2004API,
  title={A p38 inhibitor allows to dissociate differentiation and apoptotic processes triggered upon LIF withdrawal in mouse embryonic stem cells},
  author={Dani{\`e}le Duval and Michel Malaise and Barbara Reinhardt and Claude Kedinger and H{\'e}l{\`e}ne Boeuf},
  journal={Cell Death and Differentiation},
  year={2004},
  volume={11},
  pages={331-341}
}
AbstractMouse embryonic stem cells remain pluripotent when maintained in the presence of leukemia inhibitory factor (LIF). Upon LIF withdrawal, most cells differentiate into various lineages, while some die by apoptosis within 3 days. We have analyzed the activation pattern of the mitogen-activated protein kinase (MAPK) families and characterized the expression profile of selected genes modulated during differentiation or apoptosis. We show that p38 MAPKs are activated first, during the… CONTINUE READING