A p38(MAPK)/HIF-1 pathway initiated by UVB irradiation is required to induce Noxa and apoptosis of human keratinocytes.

@article{Nys2010APP,
  title={A p38(MAPK)/HIF-1 pathway initiated by UVB irradiation is required to induce Noxa and apoptosis of human keratinocytes.},
  author={Kris Nys and An Van Laethem and Carine Michiels and Noem{\'i} Rubio and Jacques G Piette and Maria Garmyn and Patrizia Agostinis},
  journal={The Journal of investigative dermatology},
  year={2010},
  volume={130 9},
  pages={2269-76}
}
The signal transduction pathways leading to apoptosis of human keratinocytes responding to UVB irradiation are complex and not completely understood. Previously, we reported that in UVB-irradiated keratinocytes, p38(MAPK) instigates Bcl-2-associated X protein (Bax) activation and mitochondrial apoptosis. However, the molecular mechanism underlying the pro-apoptotic function of p38(MAPK) remained unclear. Here, we show that in UVB-treated human primary keratinocytes the activation of p38(MAPK… CONTINUE READING