A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

@article{Wolfel1995APC,
  title={A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma},
  author={Thomas Wolfel and M. Hauer and Jörg Schneider and Manuel Serrano and C Wolfel and E Klehmann-Hieb and Etienne de Plaen and Thomas Hankeln and K H Meyer zum B{\^u}schenfelde and David H. Beach},
  journal={Science},
  year={1995},
  volume={269},
  pages={1281 - 1284}
}
A mutated cyclin-dependent kinase 4 (CDK4) was identified as a tumor-specific antigen recognized by HLA-A2. 1-restricted autologous cytolytic T lymphocytes (CTLs) in a human melanoma. The mutated CDK4 allele was present in autologous cultured melanoma cells and metastasis tissue, but not in the patient's lymphocytes. The mutation, an arginine-to-cysteine exchange at residue 24, was part of the CDK4 peptide recognized by CTLs and prevented binding of the CDK4 inhibitor p16INK4a, but not of p21… 

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