A one-pot chemoenzymatic synthesis for the universal precursor of antidiabetes and antiviral bis-indolylquinones.

@article{Schneider2007AOC,
  title={A one-pot chemoenzymatic synthesis for the universal precursor of antidiabetes and antiviral bis-indolylquinones.},
  author={Patrick A. Schneider and Monika Josefa Weber and Karen Rosenberger and D. C. Hoffmeister},
  journal={Chemistry & biology},
  year={2007},
  volume={14 6},
  pages={
          635-44
        }
}
Bis-indolylquinones represent a class of fungal natural products that display antiretroviral, antidiabetes, or cytotoxic bioactivities. Recent advances in Aspergillus genomic mining efforts have led to the discovery of the tdiA-E-gene cluster, which is the first genetic locus dedicated to bis-indolylquinone biosynthesis. We have now genetically and biochemically characterized the enzymes TdiA (bis-indolylquinone synthetase) and TdiD (L-tryptophan:phenylpyruvate aminotransferase), which… CONTINUE READING

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