• DOI:10.1016/S1074-5521(01)00085-0
Corpus ID: 18264688

A one-bead, one-stock solution approach to chemical genetics: part 1.

@article{Blackwell2001AOO,
  title={A one-bead, one-stock solution approach to chemical genetics: part 1.},
  author={H. Blackwell and L. P{\'e}rez and R. Stavenger and J. Tallarico and E. Cope Eatough and M. Foley and S. Schreiber},
  journal={Chemistry & biology},
  year={2001},
  volume={8 12},
  pages={
          1167-82
        }
}

H. Blackwell, L. Pérez, +4 authors S. Schreiber

Published 2001

Medicine, Biology

Chemistry & biology

BACKGROUND In chemical genetics, small molecules instead of genetic mutations are used to modulate the functions of proteins rapidly and conditionally, thereby allowing many biological processes to be explored. This approach requires the identification of compounds that regulate pathways and bind to proteins with high specificity. Structurally complex and diverse small molecules can be prepared using diversity-oriented synthesis, and the split-pool strategy allows their spatial segregation on… CONTINUE READING

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