A one-bead, one-stock solution approach to chemical genetics: part 1.

@article{Blackwell2001AOO,
  title={A one-bead, one-stock solution approach to chemical genetics: part 1.},
  author={H. Blackwell and L. P{\'e}rez and R. Stavenger and J. Tallarico and E. Cope Eatough and M. Foley and S. Schreiber},
  journal={Chemistry & biology},
  year={2001},
  volume={8 12},
  pages={
          1167-82
        }
}
  • H. Blackwell, L. Pérez, +4 authors S. Schreiber
  • Published 2001
  • Medicine, Biology
  • Chemistry & biology
  • BACKGROUND In chemical genetics, small molecules instead of genetic mutations are used to modulate the functions of proteins rapidly and conditionally, thereby allowing many biological processes to be explored. This approach requires the identification of compounds that regulate pathways and bind to proteins with high specificity. Structurally complex and diverse small molecules can be prepared using diversity-oriented synthesis, and the split-pool strategy allows their spatial segregation on… CONTINUE READING
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    References

    SHOWING 1-10 OF 68 REFERENCES
    A one-bead, one-stock solution approach to chemical genetics: part 2.
    • 78
    Split--pool synthesis of 1,3-dioxanes leading to arrayed stock solutions of single compounds sufficient for multiple phenotypic and protein-binding assays.
    • 52
    Decoding Products of Diversity Pathways from Stock Solutions Derived from Single Polymeric Macrobeads
    • 14
    • PDF
    Printing Small Molecules as Microarrays and Detecting Protein−Ligand Interactions en Masse
    • 337
    High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications.
    • 187
    • PDF
    Target-oriented and diversity-oriented organic synthesis in drug discovery.
    • 1,723
    • PDF