A nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expression.

@article{Grimm2011ANI,
  title={A nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expression.},
  author={Andrew A Grimm and Cynthia S. Brace and Ting Wang and Gary D. Stormo and Shin-ichiro Imai},
  journal={Aging cell},
  year={2011},
  volume={10 2},
  pages={305-17}
}
Silent information regulator 2 (Sir2) orthologs are an evolutionarily conserved family of NAD-dependent protein deacetylases that regulate aging and longevity in model organisms. The mammalian Sir2 ortholog Sirt1 regulates metabolic and stress responses through the deacetylation of many transcriptional regulatory factors. To elucidate the mechanism by which Sirt1 controls gene expression in response to nutrient availability, we devised a bioinformatic screen combining gene expression analysis… CONTINUE READING
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